The Noebels and Jiang laboratories in the Departments of Neuroscience/Neurology at Baylor College of Medicine are jointly seeking applicants for postdoc associate positions. The specific goal of the postdoc fellows for these positions is to use a multi-disciplinary approach, including single-cell RNA sequencing, Patch-seq, multi-patch clamp recording, machine learning, and complicated genetic tools to understand cellular heterogeneity and circuit organization of healthy and diseased brains. The fellows will use rodent and primate models, including surgically resected human tissue, to understand brain cell types with the molecular, spatial, and morpho-electric annotations, and how genetic lesions (related to epilepsy and autism) give rise to culprit cell types that contribute to the core symptoms of affected individuals.

You can learn more about our research at (https://www.bcm.edu/people-search/jeffrey-noebels-27644   or https://www.bcm.edu/research/labs-and-centers/faculty-labs/xiaolong-jiang-lab ) and more specific information for current projects from recent publications in our labs:

Jiang X., Shen S., Cadwell C.R., Berens P., Sinz F., Ecker A.S., Tolias A.S. (2015). Principles of Connectivity among Morphologically Defined Cell Types in Adult Neocortex. Science. Vol. 350 no. 6264 DOI: 10.1126

Cadwell CR, Palasantza A, Jiang X, Berens P, Deng Q, Yilmaz M, Reimer J, Shen S, Bethge M, Tolias KF, Sandberg R & Tolias AS (2016). Morphological, electrophysiological, and transcriptomic profiling of single neurons using Patch-seq. Nature Biotechnology, 34(2), 199-203. doi: 10.1038/nbt.3445. Epub 2015 Dec 21.

Scala F, Kobak D, Shan S, Bernaerts Y, Laturnus S, Cadwell CR, Hartmanis H, Castro J, Tan ZH, Sandberg S, Berens P, Jiang X*, Tolias AT*. Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas. Nature Communication. volume 10, Article number: 4174 (2019) *co-corresponding authors

Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JL. Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model.  J Clin Invest. 2020 May 1;130(5):2286-2300.

Miao Q, Herlitze S, Mark D, Noebels JL. Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms. Brain. 2020 Jan 1;143(1):161-174