We have an exciting opportunity for a highly motivated postdoctoral fellow with a strong background in biophysics and biochemistry to join the Pharmaceutical Development department at Genentech. The focus of this position will be to discern the physio-chemical basis of liquid-liquid phase separation (LLPS) and gelation behavior of monoclonal antibodies and similar therapeutic protein molecules at high concentration. These phenomena can negatively impact the formulation, manufacture and delivery of therapeutic proteins and are, therefore, a major concern for the department. A mechanistic understanding of the interactions driving self-association has implications for designing improved therapeutic molecules. A major objective of this position will be to develop a predictive model for antibody LLPS and gelation. Developing biophysical tools for dilute solutions that are predictive of high concentration behavior is essential for this goal.

Requirements:

• Candidate should have recently obtained or will soon obtain a PhD in one of the following fields: Biochemistry, biophysics, cell biology, or molecular biology. Computational biology skills are desirable but not required.

• Enthusiasm in tackling complex biological problems, vigorous scientific logics and solid technical skills are essential qualities.

• Qualified candidates must have strong publication record to demonstrate productivity and independent thinking.

Relevant publications:

1. Pindrus, M. et al. Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions. Mol Pharmaceut 12, 3896–3907 (2015).

2. Tesar, D. et al. Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye. Mabs 9, 1297–1305 (2017).

More Information about the Genentech Postdoctoral Program:
http://www.gene.com/careers/academic-programs/postdocs

Relocation benefits are available for this job posting.

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.