Agency

U.S. Environmental Protection Agency (EPA)

Location

Duluth, Minnesota

Job Category

Internships

Salary

TBD

Last Date to Apply

02/28/2023

Website

https://www.zintellect.com/Opportunity/Details/EPA-ORD-CCTE-GLTED-2022-15

Description

*Applications may be reviewed on a rolling-basis and this posting could close before the deadline. Click here for information about the selection process. EPA Office/Lab and Location: A research opportunity is available at the Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Computational Toxicology and Exposure (CCTE), Great Lakes Toxicology & Ecology Division (GLTED) located in Duluth, Minnesota. Research Project: This research project aims to identify the food web pathways by which insectivorous birds are exposed to PFAS at the aquatic/terrestrial interface. This specific research effort is aimed at characterizing physiological pathways at the level of the individual through which PFAS exposure may lead to a lack of fitness and/or reproductive success. Evaluation and organization of empirical evidence (toxicity literature, on-line sources, physiological data), analysis of existing and new in vitro data, and comparative physiological and toxicological data/models will aid in development and evaluation of mechanistic Adverse Outcome Pathways (AOPs) relevant to PFAS exposure in avian species. The participants efforts to delineate hypothesized AOPs will form the basis for field-based evaluations of molecular biomarkers that support causal relationships and are predictive of apical outcomes of concern to decision makers (e.g., survival, growth/development, reproduction, and population sustainability). The research participant may be involved in any or all of the following activities with guidance from the mentor: - Compiling information from the literature and from on-line data sources relevant to hazard assessment of PFAS. - Organizing existing knowledge using the adverse outcome pathway (AOP) framework and publishing AOP descriptions in the AOP-Wiki (aopwiki.org). - Developing or implementing data mining, machine-learning, and other computational methodologies to expedite organization and synthesis of existing knowledge. - Designing, planning, and implementing field-based in vivo studies to evaluate and support development of PFAS-relevant AOPs, using PFAS chemicals and other reference chemicals thought to act through similar modes of action, including: - Targeted in vivo chemical exposure experiments with local insectivorous songbird experimental populations. - Collection, processing, and analysis of biofluid and tissue samples suitable for molecular, biochemical, and histological analyses, including analyses for changes in gene expression, hormone or protein levels, and incidence of pathologies. - Generating samples for transcriptomic and metabolomic analyses and applying statistical and bioinformatic tools to analyze transcriptomics. - Conducting statistical analyses on experimental data. - Evaluating weight of evidence considering factors such as biological plausibility, empirical concordance among measured endpoints in accordance with relevant guidance documents. - Presenting research results at regional, national, and/or international conferences and workshops. - Contributing to the preparation of peer-reviewed journal articles and disseminating research results to project partners and stakeholders. Learning Objectives: The research participant can expect to learn skills in applied biochemistry, toxicology, and biology and will learn how methods in toxicology can be applied to support environmental decision making. The participant will gain experience in multiple aspects of research project planning, communication, coordination, implementation and analysis. The selected participant will collaborate with a transdisciplinary research team and engage in multiple aspects of project planning, communication and coordination, research implementation, and analysis. The research participant will be afforded an opportunity to interact with internationally recognized leaders, both within and outside EPA, in the area of toxicology and regulatory environmental science. The research participant will have the opportunity to contribute to and/or publish original research, attend and present at local and national scientific meetings, and develop collaborations with other investigators as appropriate to addressing the research problem. It is expected that this training opportunity will provide an early career scientist with knowledge, skills, and abilities needed to apply new technologies and associated data to regulatory decision-making at the local, national, and/or international scale and to pursue a professional career in life sciences research. Mentor(s): The mentor for this opportunity is Jonathan Haselman (haselman.jon@epa.gov). If you have questions about the nature of the research please contact the mentor(s). Anticipated Appointment Start Date: February 13, 2022. All start dates are flexible and vary depending on numerous factors. Click here for detailed information about start dates. Appointment Length: The appointment will initially be for one year and may be renewed up to three additional years upon EPA recommendation and subject to availability of funding. Level of Participation: The appointment is full-time. Participant Stipend: The participant will receive a monthly stipend commensurate with educational level and experience. Click here for detailed information about full-time stipends. EPA Security Clearance: Completion of a successful background investigation by the Office of Personnel Management (OPM) is required for an applicant to be on-boarded at EPA. ORISE Information: This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and EPA. Participants do not become employees of EPA, DOE or the program administrator, and there are no employment-related benefits. Proof of health insurance is required for participation in this program. Health insurance can be obtained through ORISE. ORISE offers all ORISE EPA graduate students and Postdocs a free 5 year membership to the National Postdoctoral Association (NPA). The successful applicant(s) will be required to comply with Environmental, Safety and Health (ES&H) requirements of the hosting facility, including but not limited to, COVID-19 requirements (e.g. facial covering, physical distancing, testing, vaccination). Questions: Please see the FAQ section of our website. After reading, if you have additional questions about the application process please email EPArpp@orau.org and include the reference code for this opportunity.

Qualifications

The qualified candidate should have received a master's degree in one of the relevant fields (e.g., Biology, (Eco)toxicology, Toxicology, Biochemistry, Molecular Biology, Genetics, Bioinformatics, Computational Biology, Computational Chemistry, Chemistry). Degree must have been received within five years of the anticipated appointment start date. Preferred skills: - Academic background in toxicology, computational biology, and/or molecular biology along with an interest in applied research in toxicology. - Familiarity with literature search tools and strategies - Laboratory research experience with in vivo and/or in vitro toxicology study design, data collection, statistical analyses, and a general knowledge of good laboratory practices. - Experience working with and/or handling avian species - Experience with biochemical toxicology/molecular biology techniques (e.g., measuring gene or protein expression, enzyme activity, cell-based in vitro assays, etc.) - Computer skills relating to data collection, analysis, and graphical presentation - Coursework and/or experience with statistical analysis - Course work and/or experience with biostatistics and/or bioinformatics - Computational skills (e.g., programming, R-based statistics) - Skills in oral and written communication - Skills in appropriate research data documentation and recordkeeping - Familiarity with routine quality assurance/quality control procedures for laboratory research

Contact Person

EPArpp@orau.org

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