GENERAL SUMMARY OF POSITION:  

We currently have an opening for a Research Associate to join the laboratory of Dr. Michelle Kelliher at the University of Massachusetts Medical Center. The Kelliher lab studies how leukemia develops using genetically engineered mouse models and patient derived xenografts. We are focused on understanding the molecular and cellular basis of chemoresistance and relapse in an effort to develop novel therapeutic approaches. Our lab uses innovative mouse modeling approaches and single cell sequencing and chromatin accessibility methods to identify features of leukemic stem or initiating cells thought to mediate relapse. This position offers opportunities for career development, including possibly designing and executing independent experiments which could lead to publication.

MAJOR RESPONSIBILITIES:

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  • Work collaboratively to assist Postdoctoral fellows and graduate students with research projects
  • Perform a variety of laboratory experiments using both routine and special techniques, including:
  • Molecular biology procedures such as DNA purification, PCR, gel electrophoresis, cloning, qRT-PCR, and Western blotting
  • Cell culture work 
  • Mouse colony management, breeding, and genotyping
  • Mouse experiments, injections and organ harvesting
  • Routine histology, immunohistochemistry, and immunofluorescence
  • Flow cytometry analysis 
  • Collect, record, and analyze data
  • Assist in the training of others
  • Write and provide input to improve current procedures, protocols, and/or methods
  • Prepare laboratory reagents, buffers, media, and other general lab stocks
  • Assist with lab organizational tasks, including lab equipment setup and lab supply ordering and purchasing

  SUPERVISION RECEIVED:

  Under the direction of the Principal Investigator, or designee

  
  

   

  SUPERVISION EXERCISED: 

  Supervise aides, technicians, and associates

   

  ENVIRONMENTAL WORKING CONDITIONS:

  Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens

REQUIRED QUALIFICATIONS:  

• Bachelor’s degree in the Biological Sciences, or equivalent experience
• 5 years of relevant research experience
• Knowledge of Microsoft Office products
• Strong ability to analyze complex visual data in a quantitative and objective manner
• Judgment and action skills required to solve commonly encountered problems