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Computational Biologist

Job Description

Job ID:
31753

Location:
450 Brookline Ave, Boston, MA 02215

Category:
Clinical Research

Employment Type:
Full time

Work Location:
Full Remote: 4-5 days remote/wk

Overview

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

The Center for Functional Cancer Epigenetics (CFCE) at Dana-Farber Cancer Institute is dedicated to the exploration of the key role that epigenetic alterations and abnormal transcriptional regulation play in the development and progression of cancer. A better understanding of these alterations will lead to better diagnosis for cancer and contributions to the knowledge required for the development of new therapeutics and exploiting epigenetic mechanisms. The Center’s organization and leadership represents a very tight coupling between wet-lab and informatics efforts that provide an unprecedented opportunity to advance the field.

The Computational Biologist works with the Center Staff and interacts with Principal Investigators, Researchers both within and external to the Center.  Responsibilities include analysis of all types of genomic data generated as part of the Center’s projects. Additional activities may include preparing manuscripts and grant applications.

Responsibilities

  • Interprets complex biological information. Performs tasks to reduce and consolidate output from software. Prepares data for utilization by other scientists.
  • Monitors new data from public databases, finds and loads missed data, cleans loaded data to satisfy quality control criteria.
  • Must be able to query various sources for the information needed; i.e., the Web, publications and internal DFCI resources.
  • Directs and guides DNA, RNA and protein sequence database searches and the computational analysis of resulting data.
  • Implements end-users needs in database searching and integration.
  • Maintains the computational infrastructure and controls the flow of samples and information for large-scale studies. 
  • Recognizes and reports problems with the data management process and fixes the problems whenever possible.
  • Interface with projects to perform quality control and analysis of the data
  • Develop testable hypotheses that will inform follow-up experiments and enable rapid understanding of new biological areas
  • Use state of the art bioinformatics platform that will include both collecting and housing data.
  • Contribute to the creation of biologist-friendly interface and analysis tool to allow the mining of epigenetic data

Qualifications

  • Bachelors degree required, MS preferred or PhD in bioinformatics, computer science and/or the life sciences and 0-2 years relevant experience.
  • Familiarity with simple programming using Perl/Python or Java, C/C++, statistical programming using R or related tools, web-development, and database query through SQL.
  • Familiarity with principles of experimental design and modern data analysis paradigms is required.
  • Strong interpersonal skills and ability to effectively interact with all levels of staff and external contacts.
  • Excellent analytical, organizational and time management skills.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

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