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Research Fellow- Gadue laboratory in the Center of Cellular and Molecular Therapeutics

Job Description

Research Fellow- Gadue laboratory in the Center of Cellular and Molecular Therapeutics

Full Job Description

Location: LOC_COLKET-Colket Translational Research
Req ID: 212638
Shift: Days
Employment Status: Regular - Full Time
About Us
We’re seeking breakthrough makers! Children’s Hospital of Philadelphia was built on the belief that we can change lives. Today, in every role throughout our hospital, research institute and care network, the 22,000 members of our workforce are finding new ways – big and small – to make a difference for the patients and families we serve.
If you are ready to challenge yourself, be inspired and grow – no matter what your role – you just may be the kind of breakthrough maker who will thrive at CHOP.
CHOP is proud to share that we are ranked No. 1 on Forbes' 2022 list of America's Best Large Employers!
Job Summary
We are seeking a highly motivated individual for a postdoctoral position in the Gadue laboratory in the Center of Cellular and Molecular Therapeutics at the Children’s Hospital of Philadelphia. The Gadue laboratory focuses on using human ES and iPS cell models to study human pancreatic development and diabetes. The NIH funded position aims to study multiple forms of diabetes using genome engineered stem cell lines with a focus on endocrine lineage cells. Projects available include using the stem cell model to functionally validate variants discovered by genome wide association studies and their target genes in beta cell biology, especially in regard to cellular stress and how this relates to diabetes pathogenesis. In addition, projects on the study of monogenic forms of diabetes are also available, focusing on HNF1A and its downstream targets in endocrine cell development and function. Techniques used widely in the laboratory include CRISPR based genome engineering, stem cell culture, in vitro differentiation, flow cytometry, fluorescent microscopy and various genomic techniques (RNA-seq, ATAC-seq etc...). Prior experience in some of these areas while not required would be beneficial.

The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

Job Responsibilities
  • Conduct independent scholarly research and develop new methods and protocols
  • Participate in project planning, recording and evaluation of data
  • Acquire technical, lab management and grant writing skills
  • Participate in seminars, lectures, poster sessions and presentation at national meetings
  • Supervise junior lab members
  • Assist with other research projects
Job Responsibilities (Continued)
Job Responsibilities (Continued)
Required Licenses, Certifications, Registrations
Required Education and Experience
  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
Preferred Education, Experience & Cert/Lic
Additional Technical Requirements
To carry out its mission, it is of critical importance for the Children’s Hospital of Philadelphia (CHOP) to keep our patients, families and workforce safe and healthy and to support the health of our global community. In keeping with this, CHOP has mandated all workforce members on site at any CHOP location for any portion of their time be vaccinated for COVID-19 as a condition of employment. This mandate also applies to workforce members performing work for CHOP at non-CHOP locations. Additionally, all workforce members based in or regularly scheduled to work at any New Jersey location are mandated to be both vaccinated and boosted for COVID-19, with booster timing consistent with applicable guidelines. The CHOP COVID-19 vaccine mandate is in alignment with applicable local, state and federal mandates. CHOP also requires all workforce members who work in patient care buildings or who provide patient care to receive an annual influenza vaccine. Employees may request exemption consideration for CHOP vaccine requirements for valid religious and medical reasons. Please note start dates may be delayed until candidates are fully immunized or valid exemption requests are reviewed. In addition, candidates other than those in positions with regularly scheduled hours in New Jersey, must attest to not using tobacco products.
EEO / VEVRAA Federal Contractor

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