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The CNS Stem Cell group in the Department of Laboratory Medicine and Pathology has an outstanding opportunity for a 1.0 FTE Research Scientist 3. We are seeking a motivated individual to further the investigation of Alzheimer disease and other neurodegenerative syndromes using human induced pluripotent stem cells (hiPSCs). We are a collaborative, translational team identifying cell-type specific mechanisms of genetic risk to the development of AD. In particular, this position will be focused on investigating the molecular mechanisms of sex-differences in AD.
This position will support Research activities including but not limited to:
• Generation and maintenance of iPSC lines.
• Differentiation of iPSC into progenitor neural cells and neuron/glia.
• Developing mutant and variant cell lines using CRISPR.
• Independently perform experiments measuring neuronal health, protein trafficking and AD neuropatholgocial phenotypes from iPSC-derived neurons.
• Defining and adapting neuronal and glial differentiation protocols for functional assays.
• Assist in Principal Investigator in the training as supervision of students, postdoctoral fellows and other laboratory staff.
• Contribute to grant and manuscript writing, including data collection, writing and editing and intellectual contributions.
This position requires performing laboratory research independently with supervision. The main techniques include cell culture (cell lines and pluripotent stem cells); neuronal and glial differentiations; molecular biology, gene editing with CRISPR/Cas9; Flow Cytometry and FACS, and basic cell biological techniques: immunostaining, western blotting, immunoprecipitations.
• Bachelor’ Degree in Biology, Biochemistry, Molecular Biology, Neurosciences or related field and equivalent experience can be substituted for degree requirement.
• 3 years of relevant work experience
Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.
• Masters or Doctoral degree in Biology, Biochemistry, Molecular Biology, Neurosciences or related field.
• Five years of relevant work experience.
CONDITIONS OF EMPLOYMENT
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment, you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.