A postdoctoral fellowship opportunity is immediately available in the laboratory of Dr. Charles Brenner in the Diabetes and Metabolism Research Institute (DMRI) at Beckman Research Institute of City of Hope. The Brenner laboratory examines how nicotinamide adenine dinucleotide (NAD), the central regulator of metabolism, is disturbed by diseases and conditions including cancer, neuropathy, fatty liver, postpartum and viral infection. By identifying alterations in metabolism, we identify ways to sensitize and kill cancer cells, protect damaged nerves, and improve the repair capacity of damaged tissues.
The postdoctoral fellow will dissect mechanisms of transcriptional, post-translational and metabolomic alterations as a function of metabolic stress in order to better model and develop treatments for metabolic diseases and cancer and to support good health in the face of postpartum and viral challenges. Please read more information about the laboratory at http://brennerlab.net .
Applicants are encouraged to carefully read papers downloadable from https://www.brennerlab.net/curriculumvitae/ (eg paper 129 on postpartum, 135 on glioma, or our recent work on coronavirus https://doi.org/10.1101/2020.04.17.047480 . After reading one or more recent papers, applicants should propose a question or an experiment related to work in the Brenner laboratory.
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
Basic education, experience and skills required for consideration:
- A PhD or equivalent doctoral degree is required.
- Creative work as documented by peer reviewed publications.
Preferred education experience and skills:
- Related training and experience is preferred.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.